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Nitric oxide synthase in tissues around failed hip prostheses

Paper ID Volume ID Publish Year Pages File Format Full-Text
13595 882 2002 6 PDF Available
Title
Nitric oxide synthase in tissues around failed hip prostheses
Abstract

Nineteen patients who had undergone hip revision surgery for aseptic loosening of joint prostheses were studied. Tissue samples were harvested at the interface between bone and implant, either at the stem or at the cotyle level. Immunohistochemistry was performed on tissue sections to detect nitric oxide synthase (NOS), the enzyme which enables the synthesis of nitric oxide (NO), a molecule which can activate bone resorption. Quantitative analysis of the positive cells and correlation with the presence of particulate wear debris and radiological data were performed.The authors observed a trend towards a moderate increase in positive cells due to inducible NOS in tissues containing particulate wear debris, especially of a plastic material. This increase, however, did not achieve statistical significance. On the contrary, there was a statistical correlation between iNOS (inducible NOS) and the severity of osteolysis around the prosthetic implant. Pharmacological control of the biosynthesis of NO may be considered in the prevention or treatment of loosening.

Keywords
Nitric oxide synthase; Hip joint prosthesis; Loosening; Immunohistochemistry; Bone/implant interface
First Page Preview
Nitric oxide synthase in tissues around failed hip prostheses
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 24, December 2002, Pages 4833–4838
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering