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Electrospun scaffolds of self-assembling peptides with poly(ethylene oxide) for bone tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
1360 82 2011 7 PDF Available
Title
Electrospun scaffolds of self-assembling peptides with poly(ethylene oxide) for bone tissue engineering
Abstract

Structural, mechanical and biochemical properties have to be considered when searching for suitable extracellular matrix substitutes. Fibrous structures of synthetic or natural polymers have received increasing interest as three-dimensional scaffolds for tissue engineering applications as they can be easily produced by electrospinning with different topographical features by changing the process parameters. On the other hand, the nanobiotechnology approach suggests mimicking molecular architectures in nature through self-assembly. In particular, self-assembling peptide-based biomaterials have been successfully used as scaffolds for cell growth. In order to amalgamate these two strategies nanofibrous electrospun scaffolds of hybrid polymer were designed and obtained by mixing poly(ethylene oxide) and self-assembling peptides in aqueous solution. The results of in vitro osteoblast adhesion and proliferation assays on the electrospun scaffolds obtained using different self-assembling peptide sequences are discussed.

Keywords
Electrospinning; Self-assembling peptides; Poly(ethylene oxide); h-Osteoblast adhesion; Bone tissue engineering
First Page Preview
Electrospun scaffolds of self-assembling peptides with poly(ethylene oxide) for bone tissue engineering
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 7, Issue 6, June 2011, Pages 2526–2532
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering