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Surface modification of polycaprolactone with poly(methacrylic acid) and gelatin covalent immobilization for promoting its cytocompatibility

Paper ID Volume ID Publish Year Pages File Format Full-Text
13602 882 2002 7 PDF Available
Title
Surface modification of polycaprolactone with poly(methacrylic acid) and gelatin covalent immobilization for promoting its cytocompatibility
Abstract

Polycaprolactone (PCL) membrane was modified by grafting copolymerization of methacrylic acid (MAA) initiated under UV light. The covalent immobilization of gelatin on PCL-g-PMAA surface was consequently performed by using condensing agent, 1-ethyl-3-(3-dimethylamino propyl) carbodiimide hydrochloride. The occurrence of grafting copolymerization of PMAA and further immobilization of gelatin was confirmed by ATR-FTIR and X-ray photoelectron spectroscopy characterizations. The existence of carboxyl groups grafted on PCL surface was verified quantitatively by absorbance spectroscopy where rhodamine 6G was employed to react with carboxyl groups to generate an absorbance at 512 nm. The endothelial cell culture proved that the PCL membrane slightly modified with suitable amount of PMAA or gelatin had better cytocompatibility than control PCL or PCL membrane heavily modified with PMAA or gelatin.

Keywords
Polycaprolactone; Methacrylic acid; Grafting copolymerization; Cytocompatibility
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Surface modification of polycaprolactone with poly(methacrylic acid) and gelatin covalent immobilization for promoting its cytocompatibility
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 24, December 2002, Pages 4889–4895
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us