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Porous ZrO2 bone scaffold coated with hydroxyapatite with fluorapatite intermediate layer

Paper ID Volume ID Publish Year Pages File Format Full-Text
13619 885 2003 8 PDF Available
Title
Porous ZrO2 bone scaffold coated with hydroxyapatite with fluorapatite intermediate layer
Abstract

Highly porous zirconia (ZrO2) bone scaffolds, fabricated by a replication technique using polymeric sponge, were coated with hydroxyapatite (HA). To prevent the chemical reactions between ZrO2 and HA, an intermediate fluorapatite (FA) layer was introduced. The strength of the porous ZrO2 was higher than that of pure HA by a factor of 7, suggesting the feasibility of ZrO2 porous scaffolds as load-bearing part applications. The coated HA/FA layer, with a thickness of about 30 μm, was firmly adhered to the ZrO2 body with a bonding strength of 22 MPa. The osteoblast-like cells were attached and spread well on the coating layer throughout the porous scaffolds. The alkaline phosphatase activity of the proliferated cells on the HA/FA coated ZrO2 was comparable to that on pure HA and higher than that on pure ZrO2.

Keywords
ZrO2 porous scaffold; HA coating; FA intermediate layer; Compressive strength; Adhesion strength; Cellular response
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Porous ZrO2 bone scaffold coated with hydroxyapatite with fluorapatite intermediate layer
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 19, August 2003, Pages 3277–3284
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us