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Preparation of porous hydroxyapatite scaffolds by combination of the gel-casting and polymer sponge methods

Paper ID Volume ID Publish Year Pages File Format Full-Text
13621 885 2003 10 PDF Available
Title
Preparation of porous hydroxyapatite scaffolds by combination of the gel-casting and polymer sponge methods
Abstract

A new technique of combining the gel-casting and polymer sponge methods is introduced in this study to prepare macroporous hydroxyapatite scaffolds, which provides a better control over the microstructures of scaffolds and enhances their mechanical properties. With this technique, we were able to produce scaffolds with mechanical and structural properties that cannot be attained by either the polymer sponge or gel-casting method. The scaffolds prepared have an open, uniform and interconnected porous structure with a pore size of 200–400 μm. A compressive yield strength of ∼5 MPa equivalent to that of cancellous bone and a compressive modulus of ∼8 GPa similar to that of cortical bone were achieved. The pore morphology, size, and distribution of the scaffolds were characterized using a scanning electron microscope. X-ray diffraction and Fourier transform infrared spectroscopy were used to determine the crystal structure and chemical composition of scaffolds, respectively. Scaffolds with desired porosity, pore size, and geometry can be prepared by using polymer sponges of appropriate structures.

Keywords
Scaffolds; Porous HA; Ca/P; Mechanical properties
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Preparation of porous hydroxyapatite scaffolds by combination of the gel-casting and polymer sponge methods
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 19, August 2003, Pages 3293–3302
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us