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In vitro and in vivo evaluation of chemically modified degradable starch microspheres for topical haemostasis

Paper ID Volume ID Publish Year Pages File Format Full-Text
1363 82 2011 8 PDF Available
Title
In vitro and in vivo evaluation of chemically modified degradable starch microspheres for topical haemostasis
Abstract

Degradable starch microspheres (DSMs) are starch chains cross-linked with epichlorhydrin, forming glycerol–ether links. DSMs have been used for many years for temporary vascular occlusion and drug delivery in treatment of malignancies. They are also approved and used for topical haemostasis by absorbing excess fluid from the blood and concentrating endogenous coagulation factors, thereby facilitating haemostasis. This mechanism of action is not sufficient for larger bleedings in current chemical formulations of DSMs, and modification of DSMs to trigger activation of platelets or coagulation would be required for use in such applications. Chemical modifications of DSMs with N-octenyl succinic anhydride, chloroacetic acid, acetic anhydride, diethylaminoethyl chloride and ellagic acid were performed and evaluated in vitro with thrombin generation and platelet adhesion tests, and in vivo using an experimental renal bleeding model in rat. DSMs modified to activate platelets in vitro were superior in haemostatic capacity in vivo. Further studies with non-toxic substances are warranted to confirm these results and develop the DSM as a more effective topical haemostatic agent.

Keywords
Degradable starch microspheres; Topical haemostasis; Thrombin generation; Platelet adhesion; Experimental bleeding model
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In vitro and in vivo evaluation of chemically modified degradable starch microspheres for topical haemostasis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 7, Issue 6, June 2011, Pages 2558–2565
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us