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Biomaterials and bone mechanotransduction

Paper ID Volume ID Publish Year Pages File Format Full-Text
13630 886 2001 13 PDF Available
Title
Biomaterials and bone mechanotransduction
Abstract

Bone is an extremely complex tissue that provides many essential functions in the body. Bone tissue engineering holds great promise in providing strategies that will result in complete regeneration of bone and restoration of its function. Currently, such strategies include the transplantation of highly porous scaffolds seeded with cells. Prior to transplantation the seeded cells are cultured in vitro in order for the cells to proliferate, differentiate and generate extracellular matrix. Factors that can affect cellular function include the cell–biomaterial interaction, as well as the biochemical and the mechanical environment. To optimize culture conditions, good understanding of these parameters is necessary. The new developments in bone biology, bone cell mechanotransduction, and cell–surface interactions are reviewed here to demonstrate that bone mechanotransduction is strongly influenced by the biomaterial properties.

Keywords
Adhesion; Biomaterial; Bone biology; Bone mechanotransduction; Cell–surface interaction; Cytoskeleton; Fluid flow; Gap junction; Mechanosensory cell; Microgravity; Osteoblast; Osteocyte; Shear stress; Tissue engineering
First Page Preview
Biomaterials and bone mechanotransduction
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 22, Issue 19, 1 October 2001, Pages 2581–2593
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering