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Material-dependent bone induction by calcium phosphate ceramics: a 2.5-year study in dog

Paper ID Volume ID Publish Year Pages File Format Full-Text
13634 886 2001 7 PDF Available
Title
Material-dependent bone induction by calcium phosphate ceramics: a 2.5-year study in dog
Abstract

Bone induction by different calcium phosphate biomaterials has been reported previously. With regard to (1) whether the induced bone would disappear with time due to the absence of mechanical stresses and (2) whether this heterotopically formed bone would give rise to uncontrolled growth, a long-time investigation of porous hydroxyapatite ceramic (HA), porous biphasic calcium phosphate ceramic (TCP/HA, BCP), porous α-tricalcium phosphate ceramic (α-TCP) and porous β-tricalcium phosphate ceramic (β-TCP) was performed in dorsal muscles of dog, for 2.5 years. Histological observation, backscattered scanning electron microscopy observation and histomorphometric analysis were made on thin un-decalcified sections of retrieved samples. Normal compact bone with bone marrow was found in all HA implants (n=4) and in all BCP implants (n=4), 48±4% pore area was filled with bone in HA implants and 41±2% in BCP implants. Bone-like tissue, which was a mineralised bone matrix with osteocytes but lacked osteoblasts and bone marrow, was found in all β-TCP implants (n=4) and in one of the four α-TCP implants. Both normal bone and bone-like tissues were confined inside the pores of the implants. The results show that calcium phosphate ceramics are osteoinductive in muscles of dogs. Although the quality and quantity varied among different ceramics, the induced bone in both HA and BCP ceramics did neither disappear nor grow uncontrollably during the period as long as 2.5 years.

Keywords
Bone; Calcium phosphates; Soft tissue implantation; Osteoinductive biomaterials
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Material-dependent bone induction by calcium phosphate ceramics: a 2.5-year study in dog
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 22, Issue 19, 1 October 2001, Pages 2617–2623
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us