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Interaction of poly methyl vinyl ether/maleic anhydride–dimiristoyl phosphatidylcholine: a model bioadhesion study

Paper ID Volume ID Publish Year Pages File Format Full-Text
13646 888 2000 5 PDF Available
Title
Interaction of poly methyl vinyl ether/maleic anhydride–dimiristoyl phosphatidylcholine: a model bioadhesion study
Abstract

The objective of this work is to study the interaction of a copolymer, poly methyl vinyl ether/maleic anhydride (PMV/MA) used in pharmaceutical dosage form and a phospholipid l-α-dimiristoyl phosphatidylcholine (DMPC) with the aim of developing a bioadhesive system. Glycerine is the plastifiant used to make PMV/MA insoluble. We have studied copolymer–plastifiant compatibility with differential scanning calorimetry and we have studied the influence that the solvents produce on the copolymer by infrared spectroscopy. Monolayer experiments were carried out with a Wilhelmy-type surface balance. The purpose of these experiments is to obtain molecular information about interaction PMV/MA–glycerine system with DMPC. The results show that there are attractive forces and it is a spontaneous process.

Keywords
Bioadhesion; Biomaterials; Monolayers; Poly methyl vinyl ether/maleic anhydride
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Interaction of poly methyl vinyl ether/maleic anhydride–dimiristoyl phosphatidylcholine: a model bioadhesion study
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 21, Issue 21, 1 November 2000, Pages 2131–2135
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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Any Questions? feel free to contact us