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Preparation of macroporous poly(2-hydroxyethyl methacrylate) hydrogels by enhanced phase separation

Paper ID Volume ID Publish Year Pages File Format Full-Text
13650 888 2000 7 PDF Available
Title
Preparation of macroporous poly(2-hydroxyethyl methacrylate) hydrogels by enhanced phase separation
Abstract

Macroporous poly(2-hydroxyethyl methacrylate) (p(HEMA)) hydrogels were prepared in the presence of a 0.3–0.7 m NaCl solution. The pore morphology of the p(HEMA) hydrogels was dependent on the concentration of NaCl for a constant monomer solution to aqueous solution ratio. Swelling studies showed an increase in equilibrium water content and hydrogel porosity as the NaCl concentration in the polymerization medium increased from 0 to 0.7 m. The equilibrium water content, however, decreased as the NaCl concentration in the swelling medium increased. The frozen water content increased and non-frozen water decreased with an increase in the NaCl concentration in the polymerization medium. Mechanical testing indicated that the elastic modulus of the hydrogels was not affected by the increased porosity until the pores became interconnected. These data suggest that the addition of NaCl to the polymerization medium results in a multi-phase separation during fabrication that produces macroporous hydrogels of controlled morphology.

Keywords
Poly(2-hydroxyethyl methacrylate); Porous hydrogel; Phase separation; Porosity
First Page Preview
Preparation of macroporous poly(2-hydroxyethyl methacrylate) hydrogels by enhanced phase separation
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 21, Issue 21, 1 November 2000, Pages 2163–2169
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering