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Surface engineering of poly(dl-lactic acid) by entrapment of alginate-amino acid derivatives for promotion of chondrogenesis

Paper ID Volume ID Publish Year Pages File Format Full-Text
13664 889 2002 8 PDF Available
Title
Surface engineering of poly(dl-lactic acid) by entrapment of alginate-amino acid derivatives for promotion of chondrogenesis
Abstract

Alginate-amino acid derivatives were explored to engineer poly(dl-lactic acid)(PDL-LA) as glycocalyx-like surface to promote cell adhesion and growth. Four different kinds of alginate-amino acid derivatives were synthesized to mimic the glycocalyx of cell membrane to promote chondrogenesis. The alginate-amino acid derivatives were characterized by FT-IR, 1H NMR and UV spectra and the amino acid content on alginate-amino acid derivatives was given by ninhydrin-UV method. A new strategy, entrapment, was then employed to modify PDL-LA membranes with alginate and its amino acid derivatives. The results of XPS, ATR-FTIR and contact angle confirmed that a stable thin film of alginate and its amino acid derivatives can be entrapped on the surface of PDL-LA membrane. The chondrocyte cytocompatibility test and MTT assays indicated that the alginate-amino acid derivatives modified PDL-LA membranes could promote chondrogenesis. The novel surface treatment method may have potentials for tissue engineering and other biomedical applications.

Keywords
Tissue engineering; Entrapment; Poly(dl-lactic acid); Alginate derivatives; Chondrocyte
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Surface engineering of poly(dl-lactic acid) by entrapment of alginate-amino acid derivatives for promotion of chondrogenesis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 15, August 2002, Pages 3141–3148
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us