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Preparation of alginate/galactosylated chitosan scaffold for hepatocyte attachment

Paper ID Volume ID Publish Year Pages File Format Full-Text
13681 892 2002 8 PDF Available
Title
Preparation of alginate/galactosylated chitosan scaffold for hepatocyte attachment
Abstract

Galactose-carrying lactobionic acid was covalently coupled with chitosan for determining hepatocyte specificity. Galactosylated chitosan (GC) was reacted with Ca-alginate (ALG) gel through the electrostatic interaction of carboxylic groups of alginate with amine groups of GC. Highly porous, three-dimensional sponge composed of ALG and GC was prepared to provide specific hepatocyte recognition signals and enhance the mechanical property of the ALG sponge. Observation of the sponge through scanning electron microscopy revealed that sponge was a highly porous microstructure with interconnected pores. Porosity and pore size of the sponge were greatly dependent on the content and molecular weight of GC, and freezing temperature. The mechanical property of the ALG/GC sponge was enhanced with an increase of the GC content. Spheroid formation and viability of hepatocytes of the ALG/GC sponge were higher than those of the ALG one.

Keywords
Galactosylated chitosan; Alginate; Sponge; Spheroid formation
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Preparation of alginate/galactosylated chitosan scaffold for hepatocyte attachment
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 14, July 2002, Pages 2827–2834
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Any Questions? feel free to contact us