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Lysineurethanedimethacrylate—a novel generation of amino acid based monomers for bone cements and tissue repair

Paper ID Volume ID Publish Year Pages File Format Full-Text
13684 892 2002 6 PDF Available
Title
Lysineurethanedimethacrylate—a novel generation of amino acid based monomers for bone cements and tissue repair
Abstract

A novel amino acid based dimethacrylate monomer (lysineurethanedimethacrylate, LUDM) was prepared by the addition of hydroxyethylmethacrylate (HEMA) to lysinediisocyanate (LDI). The structure was confirmed by FT-IR and 1H and 13C NMR spectroscopy as well as FAB-MS. Photopolymerized LUDM exhibited low volume shrinkage upon polymerization, good mechanical properties (Young's modulus: 3740 MPa) and high thermal stability. Osteoblast adhesion and growth on polymerized LUDM samples evidenced the biocompatibility. Further improvement of the mechanical properties was obtained by using Ca-hydroxyapatite as inorganic filler varying between 10 and 30 wt%. The Young's and flexural moduli increased with increasing filler content ranging from 3740 to 5250 MPa and from 2020 to 3690 MPa, respectively. The mechanical properties and the good biocompatibility of the lysine-based methacrylate networks make them interesting materials for medical applications, e.g. bone cements, and tissue engineering.

Keywords
Hydroxyapatite; Lysinediisocyanate; Hydroxyethylmethacrylate; Bone cement; Tissue engineering
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Lysineurethanedimethacrylate—a novel generation of amino acid based monomers for bone cements and tissue repair
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 14, July 2002, Pages 2849–2854
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
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Price after discount Only $4.95
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Full-text PDF Download
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