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Nitinol versus stainless steel stents: acute thrombogenicity study in an ex vivo porcine model

Paper ID Volume ID Publish Year Pages File Format Full-Text
13702 892 2002 9 PDF Available
Title
Nitinol versus stainless steel stents: acute thrombogenicity study in an ex vivo porcine model
Abstract

Acute and subacute stents thrombosis along with thrombus mediating neointimal proliferation within the stent struts remain major concerns in coronary stenting. Up to date, there is an obvious lack of data on the thrombogenicity of stent materials in physiological conditions. This study was performed to compare the relative thrombogenicity of nitinol versus stainless steel stents. Nitinol stents were laser cut to reproduce the exact geometry of the stainless steel Palmaz® stents and tested in an ex vivo AV shunt porcine model under controlled conditions. Nitinol stents presented only small amounts of white and/or red thrombus principally located at the strut intersections while Palmaz® stents clearly exhibited more thrombus. As a result, 125I-fibrin(ogen) adsorption and 111I-platelets adhesion were significantly lower on nitinol than on stainless steel devices (36%, p=0.03 for fibrin(ogen) and 63%, p=0.01 for platelet). These results were confirmed by scanning electron observations showing different thrombus morphologies for nitinol and stainless steel. Along with the unique mechanical properties of nitinol, its promising haemocompatibility demonstrated in our study may promote their increasing use for both peripheral and coronary revascularization procedures.

Keywords
Nitinol; Stainless steel; Stents; ex vivo shunt; Thrombogenicity; Restenosis
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Nitinol versus stainless steel stents: acute thrombogenicity study in an ex vivo porcine model
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 14, July 2002, Pages 2997–3005
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us