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Investigation of a rifampin, fusidic-acid and mupirocin releasing silicone catheter

Paper ID Volume ID Publish Year Pages File Format Full-Text
13732 895 1998 10 PDF Available
Title
Investigation of a rifampin, fusidic-acid and mupirocin releasing silicone catheter
Abstract

After strict hygienical measures have been exhausted the use of plastic materials with antibacterial activity may reduce catheter related-bacterial colonization. An antimicrobial silicone catheter was investigated by HPLC-measurement, SEM, antimicrobial assays and standard biocompatibility tests. The modified catheter was highly biocompatible and the antimicrobial leaching non-toxic. The initially release rate was governed by the drug solubility in the ‘sink’ and surface loading (‘burst effect’). The second continuous period depended on the drug velocity in the silicone matrix and was extended up to 100 days with a proportionality to t for each drug. Diffusion exponents were in range of 2×10-8 to 1×10-9 (cm2 sec-1). The lower diffusion exponent of mupirocin was explained by its higher cohesion energy and lower physico-chemical compatibility with the embedding silicone. The antimicrobial drugs were in a molecular-dispersed state with the silicone-matrix, whereas superficially located crystals of the antibiotics covering the catheter surface could be demonstrated by SEM.

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Investigation of a rifampin, fusidic-acid and mupirocin releasing silicone catheter
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 19, Issue 22, November 1998, Pages 2065-2074
Authors
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us