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Osteogenic response of hydroxyapatite cement implanted into the femur of rats with experimentally induced osteoporosis

Paper ID Volume ID Publish Year Pages File Format Full-Text
13745 897 2002 6 PDF Available
Title
Osteogenic response of hydroxyapatite cement implanted into the femur of rats with experimentally induced osteoporosis
Abstract

Hydroxyapatite (HAP) cement was implanted in the femur of rats with experimentally induced osteoporosis, and the osteogenic response was studied histomorphologically. Osteoporosis was induced with ovariectomy with either a normal diet or a low-calcium diet. The rats fed a low-calcium diet after ovariectomy showed a decrease in both cumulative photodensity and the cortical thickness index. There was significant bone conduction in the femur of these rats, but the development of new bone was late, and the affinity index was small. The change in the affinity index with time was similar between the ovariectomy group and the ovariectomy/low calcium-group, suggesting the possibility that estrogen plays a major role in bone conduction.

Keywords
Hydroxyapatite thermal decomposition product; Bioactive ceramic bone cement; Experimental osteoporosis; Biocompatibility
First Page Preview
Osteogenic response of hydroxyapatite cement implanted into the femur of rats with experimentally induced osteoporosis
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 13, July 2002, Pages 2711–2716
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering