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Crystallization at the polymer/calcium-phosphate interface in a sterilized injectable bone substitute IBS

Paper ID Volume ID Publish Year Pages File Format Full-Text
13755 897 2002 6 PDF Available
Title
Crystallization at the polymer/calcium-phosphate interface in a sterilized injectable bone substitute IBS
Abstract

Calcium phosphate (CaP) ceramics are the main raw materials used to elaborate blocks or granules for bone substitutes. In this study, injectable bone substitutes (IBS) were developed for applications in orthopedic or dental surgery. Sterile, ready-to-use composite containing CaP granules (biphasic calcium phosphate, BCP) and polymer (hydroxypropylmethylcellulose, HPMC) was prepared. Steam sterilization produced new phenomena at the CaP/polymer interface, resulting in crystal growth. These phenomena may constitute a model for the biomineralization study. Scanning electron microscopy showed that the formed crystallites organize themselves into a three-dimensional structure. Currently, the mechanisms of crystal growth are unknown and have been observed with only one combination of polymer/BCP ceramics after steam sterilization.

Keywords
Calcium phosphate ceramic; Biomaterial; Interface; Cellulose ether
First Page Preview
Crystallization at the polymer/calcium-phosphate interface in a sterilized injectable bone substitute IBS
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 13, July 2002, Pages 2789–2794
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering