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Ex vivo PMA-induced respiratory burst and TNF-α secretion elicited from inflammatory cells on machined and porous blood plasma clot-coated titanium

Paper ID Volume ID Publish Year Pages File Format Full-Text
13757 897 2002 13 PDF Available
Title
Ex vivo PMA-induced respiratory burst and TNF-α secretion elicited from inflammatory cells on machined and porous blood plasma clot-coated titanium
Abstract

The release of inflammatory mediators around implants and normal wounds may differ due to the presence of the solid surface. In this study, machined and sub-micron porous titanium implants with and without a 100 nm thick blood plasma clot were inserted subcutaneously in rat for 3 or 24 h. The cell recruitment to the interfaces, in vivo secretion of TNF-α and the ex vivo PMA-induced production of reactive oxygen species were subsequently investigated. The thin plasma clot coating gave rise to an increased ex vivo PMA-stimulated oxygen radical production by implant-associated cells at both implantation times, and an increased cell recruitment at 24 h. The total TNF-α secretion was highest at sham sites and plasma clot-coated porous titanium at 24 h. After 24 h, the cell-type pattern in the exudate around the porous plasma-coated implant was more similar to that found at sham sites than that adjacent to the non-coated implants. No differences were observed between the machined Ti and the machined sub-micron porous Ti.

Keywords
Inflammation; Plasma; Fibrinogen; Porous surfaces; Coagulation
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Ex vivo PMA-induced respiratory burst and TNF-α secretion elicited from inflammatory cells on machined and porous blood plasma clot-coated titanium
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 13, July 2002, Pages 2803–2815
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us