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In vitro evaluation of poly(ε-caprolactone-co-DL-lactide)/bioactive glass composites

Paper ID Volume ID Publish Year Pages File Format Full-Text
13765 900 2002 8 PDF Available
Title
In vitro evaluation of poly(ε-caprolactone-co-DL-lactide)/bioactive glass composites
Abstract

In vitro bioactivity of composites of poly(ε-caprolactone-co-DL-lactide) P(CL/DL-LA) containing different amounts (40, 60 and 70 wt%) of bioactive glass, S53P4, was evaluated. Two ranges of granule size of bioactive glass (<45 μm and 90–315 μm) were blended with P(CL/DL-LA) copolymer in a batch mixer. The composites were characterised by dynamic mechanical thermal analysis. The molecular weight and the melting temperature of the copolymer matrix were adjusted to enable the application of the composite material by injection below 50°C. Formation of Ca-P deposition on the surface of the composites after dissolution in simulated body fluid at 37°C was recorded by scanning electron microscopy. Degradation of the composite material was measured by water absorption and changes in the average molecular weights as a function of the dissolution time. In vitro bioactivity was found to be dependent on the weight fraction and granule size range of the bioactive glass used. The presence of the bioactive filler also accelerated the degradation compared with the neat polymer sample.

Keywords
Poly(ε-caprolactone-co-DL-lactide); Bioactive glass; Bioactive composite; Degradation
First Page Preview
In vitro evaluation of poly(ε-caprolactone-co-DL-lactide)/bioactive glass composites
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 10, May 2002, Pages 2143–2150
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering