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A novel phosphorylcholine-coated contact lens for extended wear use

Paper ID Volume ID Publish Year Pages File Format Full-Text
13786 903 2001 12 PDF Available
Title
A novel phosphorylcholine-coated contact lens for extended wear use
Abstract

The preparation and characterisation of a new phosphorylcholine (PC)-coated silicone hydrogel contact lens for use in extended wear is described. The Michael-type addition of amines to acrylates forms the basis of the synthesis of a novel silicone-based macromer with hydrophilic functionality. It is demonstrated that this macromer can be combined with other silicone-based monomers, hydrophilic monomers and crosslinker to produce a contact lenses formulation. Examples of lenses with water contents of 33% and 46% are illustrated and their properties compared to other commercially available lenses. Materials with comparatively low modulus (<0.3 MPa) and adequate tear strength (>2–4 MPa) with excellent elongation to break (>200%) can be obtained using this technology. In addition to the mechanical aspects, both the oxygen and solute permeabilities of the material can be controlled by the hydrophilic : hydrophobic monomer balance in the formulation, to obtain materials with attributes suitable for extended wear use. The PC coating is achieved by means of an in-mould coating (IMC) technique that produces a uniform and stable surface as determined by staining and XPS. The coating imparts both improved lens wettability (advancing contact angle of approximately 50° with virtually no hysteresis) and lower protein adsorption relative to the uncoated lens.

Keywords
Phosphorylcholine; Silicone hydrogel; Extended wear; Contact lens; Biocompatibility
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A novel phosphorylcholine-coated contact lens for extended wear use
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 22, Issue 24, 15 December 2001, Pages 3261–3272
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us