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Retinal pigment epithelium engineering using synthetic biodegradable polymers

Paper ID Volume ID Publish Year Pages File Format Full-Text
13795 903 2001 11 PDF Available
Title
Retinal pigment epithelium engineering using synthetic biodegradable polymers
Abstract

Retinal pigment epithelium (RPE) plays a key role in the maintenance of the normal functions of the retina, especially photoreceptors. Alteration in RPE structure and function is implicated in a variety of ocular disorders. Tissue engineering strategies using synthetic biodegradable polymers as temporary substrates for RPE cell culture and subsequent transplantation may provide a promising new therapy. In this review article, the manufacture of thin biodegradable poly(dl-lactic-co-glycolic acid) (PLGA) films and their degradation behavior in vitro are discussed. RPE cell proliferation and differentiation on these PLGA films are reviewed. The fabrication of model substrates with desired chemical micropatterns in the micrometer scale is discussed and the effects of surface patterning on RPE morphology and function are assessed. Finally, the preparation of biodegradable micropatterns with adhesive PLGA and non-adhesive poly(ethylene glycol)/PLA domains to modulate RPE cell adhesion is presented.

Keywords
Retinal pigment epithelium (RPE); Tissue engineering; Biodegradable polymers; Poly(dl-lactic-co-glycolic acid) (PLGA); Thin film; Micropatterned surfaces
First Page Preview
Retinal pigment epithelium engineering using synthetic biodegradable polymers
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 22, Issue 24, 15 December 2001, Pages 3345–3355
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering