fulltext.study @t Gmail

Degradation of poly(d,l)lactide implants with or without addition of calciumphosphates in vivo

Paper ID Volume ID Publish Year Pages File Format Full-Text
13804 909 2001 11 PDF Available
Title
Degradation of poly(d,l)lactide implants with or without addition of calciumphosphates in vivo
Abstract

The study was aimed at examining the in vivo degradation of pure poly(d,l)lactide (PDLLA) or PDLLA with an admixture of calciumphosphates. One rod (20×3×2 mm) and one cube (3×2×2 mm) of pure PDLLA, PDLLA with tricalciumphosphate (PDLLA+TCP) or PDLLA with calciumhydrogenphosphate (PDLLA+CHP), respectively, were implanted into the dorsal muscles of 50 male Wistar Albino rats. After definite intervals (from 2nd to 72nd week), pH measurements were performed in the environment of the implants. Afterwards, the cubes with their surrounding tissues were excised for histological examinations, measurements of the outer dimensions and mechanical analyses of the explanted rods were performed. No drop of more than 0.1 pH units was detectable in the tissue surrounding any type of implants. No advantageous effect of the calciumphosphates could be proved. A mild foreign body reaction could be observed around PDLLA implants. After 72 weeks, pure PDLLA had been totally resorbed from the extracellular space, the degradation of calciumphosphate-enriched PDLLA was still in progress. A large amount of inflammations occurred in the tissues surrounding PDLLA with an admixture of slowly degrading TCP or CHP, leading to two abscesses and four fistulas at PDLLA+TCP, and two abscesses and three fistulas at PDLLA+CHP implantation site. Bending strength of pure PDLLA was constant up to the 4th week post-implantation and reduced to 60% of the initial value up to the 12th week. No traces of crystallinity could be observed during the degradation of PDLLA. As a conclusion of the study, complete resorption from the extracellular space and tissue tolerance of pure PDLLA is proved. An admixture of small calciumphosphate particles is not suitable to improve the biocompatibility of PDLLA but leads to a decrease in the mechanical characteristics.

Keywords
Poly(d,l)lactide; Mechanical analysis; Calciumphosphates
First Page Preview
Degradation of poly(d,l)lactide implants with or without addition of calciumphosphates in vivo
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 22, Issue 17, September 2001, Pages 2371–2381
Authors
, , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us