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Biocompatibility testing of novel starch-based materials with potential application in orthopaedic surgery: a preliminary study

Paper ID Volume ID Publish Year Pages File Format Full-Text
13827 913 2001 8 PDF Available
Title
Biocompatibility testing of novel starch-based materials with potential application in orthopaedic surgery: a preliminary study
Abstract

This paper describes an extensive biocompatibility evaluation of biodegradable starch-based materials aimed at orthopaedic applications as temporary bone replacement/fixation implants. For that purpose, a polymer (starch/ethylene vinyl alcohol blend, SEVA-C) and a composite of SEVA-C reinforced with hydroxyapatite (HA) particles, were evaluated in both in vitro and in vivo assays. For the in vitro analysis cell culture methods were used. The in vivo tissue reactions were evaluated in an intramuscular and intracortical bone implantation model on goats, using light and scanning electron microscopy. A computerized image analysis system was used to obtain histomorphometric data regarding bone contact and remodelling after 6 and 12 weeks of implantation. In both in vitro and in vivo models, the SEVA-C-based materials did not induce adverse reactions, which in addition to their bone-matching mechanical properties makes them promising materials for bone replacement/fixation.

Keywords
Biocompatibility; Biodegradable; Bone replacement; Starch
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Biocompatibility testing of novel starch-based materials with potential application in orthopaedic surgery: a preliminary study
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 22, Issue 14, 2001, Pages 2057–2064
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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