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Sodium polyacrylate potentiates the anti-adhesion effect of a cellulose-derived polymer ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
13829 915 2001 6 PDF Available
Title
Sodium polyacrylate potentiates the anti-adhesion effect of a cellulose-derived polymer ☆
Abstract

Available methods for postoperative adhesion prevention are insufficient. A previous study demonstrated that LM-200, a bioadhesive cellulose derivative was effective in reducing adhesions. Increasing the viscosity of a polymer solution enhances the tissue separating properties. Theoretically, a combination of sodium polyacrylate (PA) and LM-200 would give more viscous solutions than LM-200 alone, and thus be more efficacious. Therefore the efficacy of various combinations of LM-200 and PA was investigated. A lesion was created in the peritoneum of mice. The solutions to be tested, or saline, were given intraperitoneally. One week post-operatively, adhesion formation was quantified and expressed as a percentage of the original lesion covered with adhesions. PA (0.01 and 0.03 wt%) given separately did not differ in adhesion reducing effect from LM-200 (p=0.3710 and 0.3481) but PA (0.1 wt%) resulted in significantly less adhesion formation (p=0.0004). The effect of LM-200 increased significantly when adding PA (0.01 wt%) (p=0.0007) or PA (0.03 wt%) (p<0.0001). When adding PA (0.1 wt%) the effect was even more pronounced (p<0.0001). The combination of a bioadhesive cellulose derivative and the polymer PA, was effective in reducing postoperative adhesion formation and a dose-dependent increase in efficacy was obtained compared to using the two components separately.

Keywords
Adhesion formation; Peritoneum; Sodium polyacrylate; Cellulose; Mice
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Sodium polyacrylate potentiates the anti-adhesion effect of a cellulose-derived polymer ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 22, Issue 16, 15 August 2001, Pages 2185–2190
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us