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Examination of in vivo influences on bioluminescent microbial assessment of corrosion product toxicity

Paper ID Volume ID Publish Year Pages File Format Full-Text
13833 915 2001 14 PDF Available
Title
Examination of in vivo influences on bioluminescent microbial assessment of corrosion product toxicity
Abstract

The composition of ionically dissolved and precipitated corrosion products from both free corrosion of ASTM F75 Co–Cr–Mo and galvanostatic polarization of Co–Cr–Mo and F138 316L stainless steel was determined using differential pulse polarography and inductively coupled plasma atomic emission spectroscopy. A bacterial bioluminescence assay, Microtox®, was used to assess the toxicity of the solid and dissolved corrosion products produced by galvanostatic polarization and the individual ions within them. The role of in vivo salinity, temperature, and protein content as modulators of corrosion product toxicity assessment was investigated empirically and mechanistically. Co–Cr–Mo products were found to be more toxic than those of 316L, and the most toxic ions were Cr6+, Ni2+, and Co2+. Ringer's solution potentiated the toxicity of the more toxic metal ions and reduced the toxicity of the less toxic ions. Using theoretical analysis in conjunction with experimental measurements, the ions in both alloys were found to interact in an antagonistic fashion. The presence of albumin was found to decrease metal toxicity, presumably by chelation.

Keywords
Toxicity; Corrosion; Microtox®; Chelation
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Examination of in vivo influences on bioluminescent microbial assessment of corrosion product toxicity
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 22, Issue 16, 15 August 2001, Pages 2215–2228
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us