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Protein adsorption and monocyte activation on germanium nanopyramids

Paper ID Volume ID Publish Year Pages File Format Full-Text
13843 915 2001 10 PDF Available
Title
Protein adsorption and monocyte activation on germanium nanopyramids
Abstract

Germanium can form defect-free pyramidal islands on Si(1 0 0)-2×1 with a height of 15 nm and a width of 60 nm. Using chemical vapor deposition we have prepared substrates with different nanopyramid densities to study the impact on contact angles, protein adsorption and cell behavior. The advancing contact angle of a water droplet of millimeter size significantly raises with nanopyramid density. The dynamic contact angle measurements reveal that the substrate surface is highly hydrophilic. On such a surface the adsorption of hydrophilic proteins, i.e. albumin and globulin, is drastically increased by the presence of nanopyramids. More important, however, the globulin is inactive after adsorption on nanopyramid edges. This observation is supported by the cytokine release of IL-1β and TNF-α of monocyte-like cell line U937. Consequently, the presence of nanopyramidal structures gives rise to less inflammatory reactions.

Keywords
Nanostructure; Germanium; AFM; Contact angle; Protein activity; Monocytes
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Protein adsorption and monocyte activation on germanium nanopyramids
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 22, Issue 16, 15 August 2001, Pages 2307–2316
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us