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Synthesis and degradation characteristics of salicylic acid-derived poly(anhydride-esters)

Paper ID Volume ID Publish Year Pages File Format Full-Text
13859 932 2000 6 PDF Available
Title
Synthesis and degradation characteristics of salicylic acid-derived poly(anhydride-esters)
Abstract

A biodegradable poly(anhydride-ester) was synthesized by melt condensation polymerization of the acetylated monomer to yield a novel polymeric prodrug. The polymer we have synthesized is composed of alkyl chains linked by ester bonds to aromatic moieties, specifically salicylic acid—the active component of aspirin. With the medicinal properties attributed to salicylic acid and the ease of metabolism, the incorporation of this compound into a polymer backbone yields a polymeric prodrug that may have potential in a variety of applications (i.e., inflammatory bowel disease). For these reasons, we have designed a synthetic scheme that yields the desired poly(anhydride-ester). The in vitro hydrolytic degradation of these polymers has been performed and results indicate that the polymer degradation rate is pH-dependent.

Keywords
Biodegradable; Poly(anhydride-ester); pH-dependent; In vitro degradation
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Synthesis and degradation characteristics of salicylic acid-derived poly(anhydride-esters)
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 21, Issue 19, October 2000, Pages 1941–1946
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us