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Response of articular cartilage and subchondral bone to internal fixation devices made of poly-l-lactide: a histomorphometric and microradiographic study on rabbits

Paper ID Volume ID Publish Year Pages File Format Full-Text
13875 935 2000 8 PDF Available
Title
Response of articular cartilage and subchondral bone to internal fixation devices made of poly-l-lactide: a histomorphometric and microradiographic study on rabbits
Abstract

To study the tissue response of articular cartilage and subchondral bone to biodegradable fixation devices, pins and rods made of poly-l-lactide with a fibers-in-matrix texture were implanted through the articular surface of the intercondylar portion of the distal rabbit femur. The initial raw material viscosity average molecular weight of the polymer was 660,000. One pin or screw was implanted per animal. The pins were cylindrical and measured 4.5 mm in transverse diameter. The screws had a core diameter of 3.2 mm and an outer diameter of 4.5 mm. At insertion, the implants were cut flush with the articular surface. After follow-up times of 36 and 48 weeks, the specimens were examined histomorphometrically and microradiographically. The intact contralateral femur served as a control for comparison. No signs of erosion or degradation of the polymer could be seen in the specimens. A brim of reparative tissue was formed at the entrance of the implant channel. The width of the reparative tissue from the tissue–implant boundary towards the center of the entrance hole varied greatly between the specimens, from 30 to 950 μm. In most specimens this bridging tissue consisted of undifferentiated mesenchymal tissue. Only two out of 24 specimens showed a near-normal metachromatic toluidine-blue staining of the matrix. Degenerative chondrocyte clustering occurred in the pre-existing cartilage within a 400 μm wide zone from the tissue–implant interface into the recipient tissues. Some new-bone formation was seen to envelop the implant in all specimens, but the fractional osteoid formation surface of the trabeculae showed a value significantly higher than that of the intact control side only in the screw-implanted 36-week specimens. Because of the long degradation time of poly-l-lactide, the restoration process of the articular cartilage was slow, and with regard to the quality and quantity of the reparative tissue, very variable. Large implants made of poly-l-lactide may not be suitable for insertion through intra-articular surfaces.

Keywords
Articular cartilage tissue response; Biodegradable; Bone response; Internal fixation; Polylactide; Rabbit
First Page Preview
Response of articular cartilage and subchondral bone to internal fixation devices made of poly-l-lactide: a histomorphometric and microradiographic study on rabbits
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 21, Issue 24, 15 December 2000, Pages 2553–2560
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering