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Enhancing effect of chitosan on peptide drug delivery across buccal mucosa

Paper ID Volume ID Publish Year Pages File Format Full-Text
13893 940 2000 5 PDF Available
Title
Enhancing effect of chitosan on peptide drug delivery across buccal mucosa
Abstract

The buccal mucosa represents a potentially important topical route for delivery of peptide or protein drugs with some unique advantages such as the avoidance of hepatic first-pass metabolism and the acidity and protease activity encountered in the gastrointestinal tract. However, the bioavailabilities or relative potencies of intraorally administered peptides are usually quite low, unless permeabilizers are employed. Chitosan, a mucopolysaccharide of marine origin, has been claimed to act both as a bioadhesive and permeabilizer, making it a candidate system for mucosal drug delivery. In this study, the enhancement effect of chitosan in gel form for oral mucosa was investigated with a large bioactive peptide, transforming growth factor-β (TGF-β). Chitosan gel was prepared at 2% concentration in dilute lactic acid and TGF-β was incorporated into the gel. The effect of chitosan as a permeabilizer was determined by measuring the flux of TGF-β across porcine oral mucosa in an in vitro system. The localization of TGF-β within the oral mucosa was determined by horizontal sectioning and counting. Chitosan was found to exert a marked permeabilizing effect on buccal mucosa for peptide drug.

Keywords
Chitosan; Penetration enhancement; Buccal drug delivery; Peptide drug
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Enhancing effect of chitosan on peptide drug delivery across buccal mucosa
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 21, Issue 20, October 2000, Pages 2067–2071
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us