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Stable modification of poly(lactic acid) surface with neurite outgrowth-promoting peptides via hydrophobic collagen-like sequence

Paper ID Volume ID Publish Year Pages File Format Full-Text
1393 83 2010 6 PDF Available
Title
Stable modification of poly(lactic acid) surface with neurite outgrowth-promoting peptides via hydrophobic collagen-like sequence
Abstract

Surface modification of poly(dl-lactic acid) (PLA) scaffolds has been performed using a biofunctional small peptide composed of collagen-like repetitive sequence and laminin-derived sequence (AG73-G3-(PPG)5) via hydrophobic interaction. The results of surface analysis suggest that AG73-G3-(PPG)5 can be stably adsorbed onto PLA films via hydrophobic interaction at the (PPG)5 region, and form an extracellular matrix-like layer composed of both structural and biosignalling sequences. In addition, neurite outgrowth of PC12 cells was observed on the AG73-G3-(PPG)5-adsorbed PLA film. These results indicate that AG73-G3-(PPG)5 very effectively enhances neurite outgrowth activity on PLA films. The hydrophobic adsorption of collagen-like peptide bound to biosignalling molecules may be widely applied as a surface modifier of PLA films for tissue engineering.

Keywords
Surface modification; PLA scaffold; Peptide adsorption; Hydrophobic interaction; Neurite outgrowth-promoting peptide
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Stable modification of poly(lactic acid) surface with neurite outgrowth-promoting peptides via hydrophobic collagen-like sequence
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 6, June 2010, Pages 1925–1930
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us