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Histological effects of iron accumulation on mice liver and spleen after administration of a metallic solution

Paper ID Volume ID Publish Year Pages File Format Full-Text
13951 977 1999 6 PDF Available
Title
Histological effects of iron accumulation on mice liver and spleen after administration of a metallic solution
Abstract

Special attention has been focused on the toxicity of some metallic species released from implanted materials, which accumulate in vital organs over long periods of time. A set of experiments with mice was designed to investigate the individual effects caused by iron in the liver and spleen. Histological features of these organs were evaluated and slight morphological changes were observed during the treatment time suggesting a negative correlation with the duration of the iron treatment. In addition, to associate the histological changes in the organs with iron accumulation an electrochemical method, adsorptive stripping voltammetry, was chosen to quantify the iron levels in these mentioned organs. The accuracy of the proposed method was checked by atomic absorption spectrometry. Both organs showed elevated concentrations of iron, nearly twofold, 7 days after iron administration compared to control organs.

Keywords
Iron; Biomaterial; Liver; Spleen; Histology; Adsorptive stripping voltammetry
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Histological effects of iron accumulation on mice liver and spleen after administration of a metallic solution
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 20, Issue 22, November 1999, Pages 2193–2198
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us