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Is cellulose sponge degradable or stable as implantation material? An in vivo subcutaneous study in the rat

Paper ID Volume ID Publish Year Pages File Format Full-Text
13953 982 1995 7 PDF Available
Title
Is cellulose sponge degradable or stable as implantation material? An in vivo subcutaneous study in the rat
Abstract

The long-term behaviour of cellulose sponge implants, 10×10×5 mm in size, and tissue reactions in and around them were examined in the subcutaneous tissue of the rat from 1 to 60 weeks after implantation. The cellulose sponge used was filled up with connective tissue 4 to 8 weeks after implantation. Histologically, moderate foreign body tissue reaction inside the implant, the appearance of cracks and fissures, spotty colouration, and softening of the pore walls were observed up to 16 weeks after implantation. Later, the foreign body reaction inside the sponge became milder, the spotty colouration disappeared and micropores enlarged in the viscose cellulose matrix. Histomorphometrically, the cross-sectional area of the implants and the size of the pore wall fragments decreased, and the number of pore wall fragments increased significantly. The cellulose sponge used can be regarded as a slowly degradable implantation material. However, the time needed for the total disappearance of the cellulose sponge from subcutaneous tissue is longer than the 60 weeks.

Keywords
Biocompatibile material; Cellulose; Implants, Artificial; Connective tissue; Granulation tissue; Rat, Sprague–Dawley
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Is cellulose sponge degradable or stable as implantation material? An in vivo subcutaneous study in the rat
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 20, Issue 21, November 1999, Pages 1989–1995
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us