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Hydroxyapatite fiber reinforced poly(α-hydroxy ester) foams for bone regeneration

Paper ID Volume ID Publish Year Pages File Format Full-Text
13967 985 1998 9 PDF Available
Title
Hydroxyapatite fiber reinforced poly(α-hydroxy ester) foams for bone regeneration
Abstract

A process has been developed to manufacture biodegradable composite foams of poly(DL-lactic-co-glycolic acid) (PLGA) and hydroxyapatite short fibers for use in bone regeneration. The processing technique allows the manufacture of three-dimensional foam scaffolds and involves the formation of a composite material consisting of a porogen material (either gelatin microspheres or salt particles) and hydroxyapatite short fibers embedded in a PLGA matrix. After the porogen is leached out, an open-cell composite foam remains which has a pore size and morphology defined by the porogen. By changing the weight fraction of the leachable component it was possible to produce composite foams with controlled porosities ranging from 0.47±0.02 to 0.85±0.01 (n=3). Up to a polymer : fiber ratio of 7 : 6, short hydroxyapatite fibers served to reinforce low-porosity PLGA foams manufactured using gelatin microspheres as a porogen. Foams with a compressive yield strength up to 2.82±0.63 MPa (n=3) and a porosity of 0.47±0.02 (n=3) were manufactured using a polymer : fiber weight ratio of 7 : 6. In contrast, high-porosity composite foams (up to 0.81±0.02, n=3) suitable for cell seeding were not reinforced by the introduction of increasing quantities of hydroxyapatite short fibers. We were therefore able to manufacture high-porosity foams which may be seeded with cells but which have minimal compressive yield strength, or low porosity foams with enhanced osteoconductivity and compressive yield strength.

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Hydroxyapatite fiber reinforced poly(α-hydroxy ester) foams for bone regeneration
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 19, Issue 21, November 1998, Pages 1935-1943
Authors
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us