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In vitro degradation of a poly(propylene fumarate)-based composite material

Paper ID Volume ID Publish Year Pages File Format Full-Text
13989 996 1996 4 PDF Available
Title
In vitro degradation of a poly(propylene fumarate)-based composite material
Abstract

We investigated the in vitro degradation of a novel degradable polymeric composite material being developed to function as a temporary replacement for trabecular bone. This material is based on a mixture of poly(propylene fumarate) cross-linked by N-vinyl pyrrolidone and includes sodium chloride and β-tricalcium phosphate. Using an in vitro test in simulated body fluids, the compressive strengths and compressive moduli of two composite materials increased with degradation time and remained above the minimum values acceptable for trabecular bone substitutes. A compressive strength of 21.3 (± 0.4) MPa and a compressive modulus of 696 (± 53) MPa were measured after twelve weeks for a composite material with initial strength of 18.0 (± 4.6) MPa and initial modulus of 113 (± 40) MPa. This unexpected phenomenon may prove to be useful for orthopaedic applications.

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In vitro degradation of a poly(propylene fumarate)-based composite material
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 17, Issue 22, November 1996, Pages 2127-2130
Authors
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us