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Evaluation of asymmetric poly(vinyl alcohol) membranes for use in artificial islets

Paper ID Volume ID Publish Year Pages File Format Full-Text
13991 996 1996 7 PDF Available
Title
Evaluation of asymmetric poly(vinyl alcohol) membranes for use in artificial islets
Abstract

Islets of Langerhans surrounded by a semipermeable membrane to prevent the host immunosystem is a potential way to treat type I diabetes mellitus. In this study, a series of poly (vinyl alcohol) membranes were formed by adding polyethylene glycols to create pores in the skin layer. The permeability study showed the skin layer structure had an influence on the diffusion of low molecular weight glucose, vitamin B12 and insulin. The mass transfer coefficient was improved from 1.04 × 10−4 to 2.16 × 10−4cm/ sec for glucose, from 2.84 × 10−5 to 8.36 × 10−5 cm/sec for vitamin B12 and from 1.45 × 10−6 to 4.15 × 10−6 cm/sec for insulin, whereas the passage of immunoglobulin G was completely prevented, indicating that these membranes could be effective in protecting islets from immunorejection. Thus such a membrane is an alternative potential material for artificial islets. In addition, we examined the insulin secretory response of islets separated by a poly(vinyl alcohol) membrane. We found that the insulinsecretion rate is relatively rapid compared to the permeation rate of insulin; thus, the process of the artificial islets is insulin-diffusion-controlled.

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Evaluation of asymmetric poly(vinyl alcohol) membranes for use in artificial islets
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 17, Issue 22, November 1996, Pages 2139-2145
Authors
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us