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Stability study of nanoparticles of poly(ɛ-caprolactone), poly(d,l-lactide) and poly(d,l-lactide-co-glycolide)

Paper ID Volume ID Publish Year Pages File Format Full-Text
13997 996 1996 7 PDF Available
Title
Stability study of nanoparticles of poly(ɛ-caprolactone), poly(d,l-lactide) and poly(d,l-lactide-co-glycolide)
Abstract

The objective was to evaluate the stability of nanoparticles prepared with poly(ɛ-caprolactone), poly(d,l-lactide) and poly(d,l-lactide-co-glycolide) polymers and stored at different temperatures and in different media. The stability parameters studied were molecular weight and crystallinity of the polymer, nanoparticle size and pH. The results show that the stability of polymeric nanoparticles depends on (i) the type of polymers with the following increasing order of polymer stability: PLA25GA50 < PLA37.5GA25 < PLA50 = PCL, (ii) the storage temperature: PCL and PLA50 nanoparticles can be kept at 4 °C and RT during one year, while PLA37.5GA25 and PLA25GA50 nanoparticles have to be stored at 4 °C, and (iii) the storage conditions: buffering or freeze-drying nanoparticles improves stability.

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Stability study of nanoparticles of poly(ɛ-caprolactone), poly(d,l-lactide) and poly(d,l-lactide-co-glycolide)
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 17, Issue 22, November 1996, Pages 2191-2197
Authors
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
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Online Support
Any Questions? feel free to contact us