fulltext.study @t Gmail

Long-term in vivo performance and biocompatibility of poly(vinyl alcohol) hydrogel macrocapsules for hybrid-type artificial pancreas

Paper ID Volume ID Publish Year Pages File Format Full-Text
14006 1058 1996 6 PDF Available
Title
Long-term in vivo performance and biocompatibility of poly(vinyl alcohol) hydrogel macrocapsules for hybrid-type artificial pancreas
Abstract

A bag-shaped macrocapsule suitable for Langerhans islets entrapment and immunoisolation was constructed using a semipermeable hydrogel membrane of poly(vinyl alcohol) (PVA) cross-linked chemically and sterilized by a radiation method. Empty (not seeded with Langerhans islets), sealed, sterile macrocapsules were implanted into the intraperitoneal cavity of adult female Buffalo rats for periods of up to 6.5 months. Long-term in vivo performance of the macrocapsule membrane was evaluated on the basis of the permeability measurements of glucose and albumin. The results of experiments revealed the progressive, disadvantageous alterations of the PVA hydrogel membrane resulting in a decrease in the permeability of solutes. Histochemical examinations of the cellular enzyme activities in the implant-encapsulating tissue, regarding the acid and alkaline phosphatases, were performed to evaluate the activity of cells involved in the inflammatory response to the long-term macrocapsule implantation.

First Page Preview
Long-term in vivo performance and biocompatibility of poly(vinyl alcohol) hydrogel macrocapsules for hybrid-type artificial pancreas
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 17, Issue 24, 1996, Pages 2351-2356
Authors
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us