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Acidity near eroding polylactide-polyglycolide in vitro and in vivo in rabbit tibial bone chambers

Paper ID Volume ID Publish Year Pages File Format Full-Text
14009 1058 1996 8 PDF Available
Title
Acidity near eroding polylactide-polyglycolide in vitro and in vivo in rabbit tibial bone chambers
Abstract

Eroding poly(dl-lactide-co-glycolide) (PDLLG) washers were observed chronically in vitro and in vivo following loading in a bone chamber tibial implant (BCl). Images were recorded using intravital microscopy of the implanted rabbit and direct pH measurements were obtained of the tissue in the bone chamber using a combination probe-reference microelectrode. While statistically significant pH differences were found between the control (unloaded) and experimental (PDLLG-bearing) BCls, they were only of the order of 0.2 pH units. This value proved to be physiologically insignificant as no statistically significant difference in bone defect healing, as indicated by angiogenesis, was detected. It was shown that the measured small pH changes during PDLLG washer erosion would result whether the buffer was phosphate-buffered saline replaced weekly or interstitial fluid subject to vascular exchanges.

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Acidity near eroding polylactide-polyglycolide in vitro and in vivo in rabbit tibial bone chambers
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 17, Issue 24, 1996, Pages 2373-2380
Authors
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
Online Support
Any Questions? feel free to contact us