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Cytokine production and adhesive protein expression by endothelial cells after contact with polyethylene terephthalate

Paper ID Volume ID Publish Year Pages File Format Full-Text
14020 1062 1996 6 PDF Available
Title
Cytokine production and adhesive protein expression by endothelial cells after contact with polyethylene terephthalate
Abstract

The authors have evaluated adhesive protein expression and cytokine production by human umbilical vein endothelial cells cultured in contact with polyethylene terephthalate (PET). ELAM-1, ICAM-1 and VCAM-1 expression was determined by flow cytometry; the concentration of interleukin-1α (IL-1α), interleukin-6 (IL-6), granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) in the supernatant was determined by enzyme immunoassay. The contact with PET determined a significant increase in ELAM-1 expression and insignificant increase in cytokine production, demonstrating that PET had a limited capability to stimulate endothelial cells in a pro-inflammatory sense.

First Page Preview
Cytokine production and adhesive protein expression by endothelial cells after contact with polyethylene terephthalate
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 17, Issue 21, November 1996, Pages 2071-2076
Authors
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering