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Influence of wall shear rate on parameters of blood compatibility of intravascular catheters

Paper ID Volume ID Publish Year Pages File Format Full-Text
14040 1069 2002 8 PDF Available
Title
Influence of wall shear rate on parameters of blood compatibility of intravascular catheters
Abstract

Three polymeric materials (silicone, PVC and nylon) were compared in an in vitro perfusion model, whereby 5 ml whole blood were perfused along 1 m lengths of polymeric tubing of 1 mm internal diameter at wall shear rates of up to 1000 s−1. Perfusion took place at 37 °C for 30 min. The polymers were investigated for platelet activation, granulocyte secretion, complement activation and contact phase activation. These parameters were also analysed in static contact for comparison. All the parameters measured displayed a dependence on wall shear rate. In all the materials studied, platelet adhesion and platelet activation increased with increasing flow rate. Granulocyte elastase release increased slightly with increasing flow rate up to 300 s−1. Complement activation was greatest for PVC at 1000 s−1, greatest for nylon at 100 s−1, but there was no measurable difference at either rate for silicone. All samples caused an increase in clotting time with increasing wall shear rate. PVC was the most platelet compatible material, nylon the worst. Silicone caused least contact phase activation, PVC and nylon the most.

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Influence of wall shear rate on parameters of blood compatibility of intravascular catheters
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 17, Issue 20, October 1996, Pages 1995-2002
Authors
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering