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Gelatin microspheres: influence of preparation parameters and thermal treatment on chemico-physical and biopharmaceutical properties

Paper ID Volume ID Publish Year Pages File Format Full-Text
14042 1069 2009 12 PDF Available
Title
Gelatin microspheres: influence of preparation parameters and thermal treatment on chemico-physical and biopharmaceutical properties
Abstract

The aim of this paper was to investigate the influence of preparation parameters on gelatin microspheres production, chemico-physical characteristics and drug encapsulation. In particular, we focussed our attention on the manufacturing parameters such as amount of polymer, stirring speed, presence and concentration of surfactants. As model drugs, TAPP-Br, clonidine hydrochloride and bromocriptine mesylate were chosen in order to compare their encapsulation and release characteristics with microspheres. In the second part of this work, a study of the influence of thermal treatment on the microspheres is reported, performed with the aim to possibly modify gelatin dissolution and drug release. In particular, the effect of this treatment was evaluated on microsphere characteristics such as swelling, porosity and dissolution, and finally on the release profiles of the encapsulated drugs.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 17, Issue 20, October 1996, Pages 2009-2020
Authors
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us