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Biomimetic implant coatings

Paper ID Volume ID Publish Year Pages File Format Full-Text
14056 1072 2007 6 PDF Available
Title
Biomimetic implant coatings
Abstract

Biomaterials and tissue engineering technologies are becoming increasingly important in biomedical practice, particularly as the population ages. Cellular responses depend on topographical properties of the biomaterial at the nanometer scale. Structures on biomaterial surfaces are used as powerful tools to influence or even control interactions between implants and the biological system [Kawahara, H., Soeda, Y., Niwa, K., Takahashi, M., Kawahara, D., Araki, N., 2004. J. Mater. Sci. Mater. Med. 15 (12), 1297–1307; Winkelmann, M., Gold, J., Hauert, R., Kasemo, B., Spencer, N.D., Brunette, D.M., Textor, M., 2003. Biomaterials 24 (7), 1133–1145]. The influence of nanometer sized surface structures on osteoblastlike cell interactions was tested with niobium oxide coatings on polished titanium slices (cp-Ti grade 2). The aim of the study was to investigate the influence of nanoscopic surface structures on osteoblast interactions in order to support collagen I production and cell adhesion. The coatings were done by means of the sol–gel process. The surface structure was adjusted by annealing of the metaloxide ceramic coatings due to temperature depended crystal growth. The applied annealing temperatures were 450, 550 and 700 °C for 1 h, corresponding to Ra-numbers of 7, 15 and 40 nm. The surfaces were characterized by means of AFM, DTA/TG, diffractometry and white light interferometry. The cell reactions were investigated concerning adhesion kinetics, migration, spreading, cell adhesion, and collagen I synthesis. The smooth surface (Ra = 7 nm) resulted in the fastest cell anchorage and cell migration. The closest cell adhesion was reached with the surface structure of Ra = 15 nm. The roughest surface (Ra = 40 nm) impedes the cell migration as well as a proper spreading of the cells. The best results concerning cell adhesion and spreading was reached with an intermediate surface roughness of Ra = 15 nm of the niobium oxide coating on cp-titanium slices.

Keywords
Nanostructure; Nanosized topography; Osteoblast; Biomaterial interaction; Surface modification
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Biomimetic implant coatings
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomolecular Engineering - Volume 24, Issue 1, February 2007, Pages 27–32
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us