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Fabrication of a three-dimensional nanostructured biomaterial for tissue engineering of bone

Paper ID Volume ID Publish Year Pages File Format Full-Text
14063 1072 2007 6 PDF Available
Title
Fabrication of a three-dimensional nanostructured biomaterial for tissue engineering of bone
Abstract

A plasma process for the surface modification of HA powders has been developed. Acrylic acid and acrylic acid/octadiene plasma deposited films onto HA particles have demonstrated to interact with SBF allowing the calcium dissolution–precipitation mechanism. Therefore, a nanostructured composite between HA and a self-assembling peptide scaffold (RAD16-I) has been developed. The differentiation of mESC in this scaffold has been studied, in order to test the osteogenic capacity of the new composite material. We have observed that the mESC can be iduced to produce Ca salts (mineralization) in a 3D-microenvironment and moreover, this activity can be enhanced by the presence of HA particules into the nanofiber scaffold.

Keywords
Cartilage; Hydroxyapatite; Bone tissue engineering; Nanostructured composite
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Fabrication of a three-dimensional nanostructured biomaterial for tissue engineering of bone
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomolecular Engineering - Volume 24, Issue 1, February 2007, Pages 75–80
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us