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Vascular prostheses with controlled release of antibiotics: Part 1: Surface modification with cyclodextrins of PET prostheses

Paper ID Volume ID Publish Year Pages File Format Full-Text
14076 1072 2007 5 PDF Available
Title
Vascular prostheses with controlled release of antibiotics: Part 1: Surface modification with cyclodextrins of PET prostheses
Abstract

Vascular prostheses were functionalised with the aim to obtain a slow release of antibiotics in order to reduce postoperative infections. The original process that we present in this paper is based on the use of a family of cage molecules named cyclodextrins (CD). These compounds have the ability to form reversible inclusion complexes with drugs such as antibiotics. The aim of this work was to graft CD onto the prosthesis, so that an antibiotic can be bound on it by this inclusion phenomenon, and then be progressively released over a prolonged period by a complex dissociation mechanism. This paper presents the first part of this research program and concerns mainly the study of the functionalization parameters. It presents surface characterization results of the modified prostheses.The PET prostheses were immersed into a solution containing a cross linking agent, cyclodextrins (β-CD, γ-CD, HP-β-CD and HP-γ-CD) and a catalyst and were padded. Grafting occurred by the mean of a thermofixation step at a temperature comprised between 140 and 180 °C. It was observed that the support was permanently modified when the CD polymer that coated the fibres resisted to the final washing process. Grafting rates of 12 wt% in CD polymer could be reached. It was also observed that the fibre coating reaction induced an increase of the permeability of the grafts.

Keywords
PET vascular prosthesis; Cyclodextrins; Citric acid; Grafting; Wettability; Permeability
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Vascular prostheses with controlled release of antibiotics: Part 1: Surface modification with cyclodextrins of PET prostheses
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomolecular Engineering - Volume 24, Issue 1, February 2007, Pages 149–153
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us