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Modificomics: Posttranslational modifications beyond protein phosphorylation and glycosylation

Paper ID Volume ID Publish Year Pages File Format Full-Text
14090 1147 2007 9 PDF Available
Title
Modificomics: Posttranslational modifications beyond protein phosphorylation and glycosylation
Abstract

Posttranslational modifications of proteins possess key functions in the regulation of various cellular processes. While they facilitate fast, location-specific and transient reactions to changing conditions in the first place they enhance the already high complexity of a cellular proteome by orders of magnitude. Furthermore, they can utterly alter the properties of the modified protein, thus making a timely analysis even more difficult. While several standardized methods for the analysis of protein phosphorylation and glycosylation have been established most other modifications require tailor-made solutions for a comprehensive analysis. Therefore, we will provide guidelines for the analysis of some important posttranslational modifications that are underrepresented in contemporary literature.

Keywords
Posttranslational modification; Sulfation; Nitrosylation; Lipidation; Protein oxidation
First Page Preview
Modificomics: Posttranslational modifications beyond protein phosphorylation and glycosylation
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomolecular Engineering - Volume 24, Issue 2, June 2007, Pages 169–177
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering