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Studies on bound water restrained by poly(2-methacryloyloxyethyl phosphorylcholine): Comparison with polysaccharide–water systems

Paper ID Volume ID Publish Year Pages File Format Full-Text
1410 83 2010 6 PDF Available
Title
Studies on bound water restrained by poly(2-methacryloyloxyethyl phosphorylcholine): Comparison with polysaccharide–water systems
Abstract

The structural change of water restrained by poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) was investigated by differential scanning calorimetry (DSC), since the biocompatibility of PMPC and related biopolymers is affected by the structure of water on the polymer surface. The phase transition behaviour of PMPC–water systems with a water content (Wc = mass of water/mass of dry sample, g g−1) in the range 0–2.0 was measured in the temperature range −150 to 50 °C. Glass transition, cold crystallization and melting were observed. Cold crystallization, which has been suggested as an index of biocompatibility, was detected for PMPC with a Wc in the range 0.5–0.9. The amounts of two types of bound water, non-freezing water and freezing bound water, were calculated from the melting enthalpy. The amount of non-freezing water of PMPC was ∼0.48. It was found that the phase transition behaviour and amount of bound water of PMPC were quite similar to those of water-soluble polysaccharide electrolytes. The results indicate that the bound water, not the free water, is restrained by PMPC.

Keywords
Poly(2-methacryloyloxyethyl phosphorylcholine); Polysaccharides; Non-freezing water; Freezing bound water; Differential scanning calorimetry
First Page Preview
Studies on bound water restrained by poly(2-methacryloyloxyethyl phosphorylcholine): Comparison with polysaccharide–water systems
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 6, Issue 6, June 2010, Pages 2077–2082
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering