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Glutathione transferases in the genomics era: New insights and perspectives

Paper ID Volume ID Publish Year Pages File Format Full-Text
14105 1148 2006 21 PDF Available
Title
Glutathione transferases in the genomics era: New insights and perspectives
Abstract

In the last decade the tumultuous development of “omics” greatly improved our ability to understand protein structure, function and evolution, and to define their roles and networks in complex biological processes. This fast accumulating knowledge holds great potential for biotechnological applications, from the development of biomolecules with novel properties of industrial and medical importance, to the creation of transgenic organisms with new, favorable characteristics.This review focuses on glutathione transferases (GSTs), an ancient protein superfamily with multiple roles in all eukaryotic organisms, and attempts to give an overview of the new insights and perspectives provided by omics into the biology of these proteins. Among the aspects considered are the redefinition of GST subfamilies, their evolution in connection with structurally related families, present and future biotechnological outcomes.

Keywords
Omics; Protein families; Thioredoxin fold; Evolution; Forced evolution; Transgenics
First Page Preview
Glutathione transferases in the genomics era: New insights and perspectives
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomolecular Engineering - Volume 23, Issue 4, September 2006, Pages 149–169
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering