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Fibrils of different collagen types containing immobilised proteoglycans (PGs) as coatings: Characterisation and influence on osteoblast behaviour

Paper ID Volume ID Publish Year Pages File Format Full-Text
14124 1175 2007 4 PDF Available
Title
Fibrils of different collagen types containing immobilised proteoglycans (PGs) as coatings: Characterisation and influence on osteoblast behaviour
Abstract

Collagen, the main organic component of bone, is used as a coating on titanium implants and as a scaffold material in bone tissue engineering. Surface modifications of titanium which promote osteoblast adhesion, proliferation and synthesis of collagen by osteoblasts are desirable. One biomimetic approach is the coating of titanium with collagen in fibrillar form. Other organic components of bone may be bound to fibrils and exert additional effects. In this study, the collagen types I–III were compared regarding their ability to bind the proteoglycans decorin and biglycan, which are found in bone. More collagen was bound to collagen II fibrils than to those of types I and III. Therefore, titanium surfaces were coated with fibrils of collagen type II containing biglycan or decorin or neither to investigate the effect of the proteoglycans on human primary osteoblast behaviour. In addition, the growth factor TGF-β1 was adsorbed onto surfaces coated with fibrils of collagen type II containing biglycan or decorin or neither to investigate the influence of decorin and biglycan on the effect of TGF-β1 on osteoblasts. Fibril-bound biglycan and decorin influence primary osteoblast behaviour by themselves. The presence of substrate-bound biglycan or decorin influences the effect of TGF-β1. These results may be important when designing collagen-based coatings or scaffolds for tissue engineering, including those loaded with growth factors.

Keywords
Collagen; Decorin; Biglycan; TGF-β1; Titanium; Osteoblast
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Fibrils of different collagen types containing immobilised proteoglycans (PGs) as coatings: Characterisation and influence on osteoblast behaviour
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomolecular Engineering - Volume 24, Issue 5, November 2007, Pages 455–458
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us