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Functionalization of PVDF membranes with carbohydrate derivates for the controlled delivery of chlorhexidin

Paper ID Volume ID Publish Year Pages File Format Full-Text
14128 1175 2007 5 PDF Available
Title
Functionalization of PVDF membranes with carbohydrate derivates for the controlled delivery of chlorhexidin
Abstract

Maltodextrin (MX) was fixed onto PVDF membranes in order to create a drug delivery Guided Tissue Regeneration (GTR) device with controlled drug delivery properties. PVDF microporous membranes were treated by a mixture of MX and citric acid, resulting to an 18 wt% increase of the supports. MX grafted membrane could capture 103 mg/g chlorhexidin digluconate (DigCHX) instead of 1 mg/g for a virgin membrane. A neutralization step was performed before the biological tests. Viability tests confirmed the non-toxicity of the MX polymer coating after neutralisation. In vitro release test in human plasma, and microbiological tests showed that membranes grafted with MX were more performing compared to virgin and β-CD grafted membranes. The antimicrobial activity was effective during more than 72 h.

Keywords
PVDF membrane; Cyclodextrin; Maltodextrin; Chlorhexidine; Cytocompatibility; Microbiology; Controlled release; Guided Tissue Regeneration
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Functionalization of PVDF membranes with carbohydrate derivates for the controlled delivery of chlorhexidin
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomolecular Engineering - Volume 24, Issue 5, November 2007, Pages 472–476
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us