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RGD peptides grafting onto poly(ethylene terephthalate) with well controlled densities

Paper ID Volume ID Publish Year Pages File Format Full-Text
14129 1175 2007 6 PDF Available
Title
RGD peptides grafting onto poly(ethylene terephthalate) with well controlled densities
Abstract

The aim of this study was to graft RGD peptides with well controlled densities onto poly(ethylene terephthalate) (PET) film surfaces. Biomimetic modifications were performed by means of a four-step reaction procedure: surface modification in order to create –COOH groups onto polymer surface, coupling agent grafting and finally immobilization of peptides. The originality of this work is to evaluate several grafted densities peptides. Toluidine blue and high-resolution μ-imager (using [3H]-Lys) were used to evaluate densities. Moreover, μ-imager has exhibited the stability of peptides grafted onto the surface when treated under harsh conditions. Benefits of the as-proposed method were related to the different concentrations of peptides grafted onto the surface as well as the capacity of RGD peptide to interact with integrin receptors.

Keywords
Biomaterial; RGD density; Grafting; PET
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RGD peptides grafting onto poly(ethylene terephthalate) with well controlled densities
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomolecular Engineering - Volume 24, Issue 5, November 2007, Pages 477–482
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us